The NeuroReset: Restoring Autonomic Balance at the Biological Root with Dr. Jonathann Kuo

About Our Guest

Dr. Jonathann Kuo, MD is a double board-certified physician in anesthesiology and pain management, and one of New York’s most respected interventional specialists. While Dr. Kuo built his reputation as an elite pain management specialist, his research into the sympathetic nervous system opened an entirely new frontier. His work on the sympathetic nervous system helped pave the way for interventional mental health to gain widespread recognition as a highly effective approach for treatment-resistant conditions.

Show Notes & Resources

In this episode, we sit down with Dr. Jonathann Kuo to explore how resetting the autonomic nervous system can change the way we experience stress, sleep, mood, and even chronic illness. He walks us through his journey from anesthesiology and interventional pain management into what he calls interventional longevity, where procedures are used to shift physiology at the root level. We dive into his NeuroReset protocol, including dual sympathetic nerve blocks, vagus nerve hydrodissection, and ketamine infusions, and he explains the mechanisms behind each step. He shares data on PTSD, anxiety, long COVID, POTS, and vasomotor symptoms, along with what he has seen in thousands of patients. We also hear about investigational approaches like liposomal anesthetics, pulsed radiofrequency, and even Botox to the sympathetic chain.

Topics discussed in this episode include:

What NeuroReset aims to change inside fight-or-flight physiology.How stress patterns can still appear despite normal labs and testing.Why PTSD patterns often involve sympathetic overdrive and emotional reactivity.How NeuroReset combines sympathetic calming with vagus nerve support.What ketamine may add for mood, plasticity, and deeper resetting.Why chronic stress can strengthen fear signaling inside the brain.How a stellate ganglion block may lower fear-center dominance.What vagus nerve hydrodissection can do for compression and function.Why dextrose, peptides, and exosomes have entered the nerve-repair conversation.How investigational add-ons raise questions about response, safety, and duration.Why Botox and pulsed radiofrequency are explored for lasting results.What patients may notice during treatment, including calm and grounding.How the best responses often show changes in sleep, HRV, and reactivity.How repeated sessions may support symptoms that return over time.Why nervous system care still requires sleep, movement, and recovery habits.What chronic stress may do to metabolism, immunity, aging, and mood.

Dr. Kuo on Instagram: https://www.instagram.com/dr.kuo

Extension Health: https://extension.health

Extension Health on Instagram: https://www.instagram.com/extension.health

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